COVID-19: VACCINE WATCH

Malaria drug shows no benefit in another coronavirus study

May 7, 2020, 4:26 PM
FILE - This Monday, April 6, 2020 file photo shows an arrangement of hydroxychloroquine tablets in ...
FILE - This Monday, April 6, 2020 file photo shows an arrangement of hydroxychloroquine tablets in Las Vegas. According to results released on Thursday, May 7, 2020, a new study finds no evidence of benefit from a malaria drug widely promoted as a treatment for coronavirus infection. Hydroxychloroquine did not lower the risk of dying or needing a breathing tube in a comparison that involved nearly 1,400 consecutive patients treated at Columbia University Irving Medical Center in New York. (AP Photo/John Locher)
(AP Photo/John Locher)

(AP) — A new study finds no evidence of benefit from a malaria drug widely promoted as a treatment for coronavirus infection.

Hydroxychloroquine did not lower the risk of dying or needing a breathing tube in a comparison that involved nearly 1,400 patients treated at Columbia University in New York, researchers reported Thursday in the New England Journal of Medicine.

Although the study is observational rather than a rigorous experiment, it gives valuable information for a decision that hundreds of thousands of COVID-19 patients have already had to make without clear evidence about the drug’s risks and benefits, some journal editors and other doctors wrote in an editorial.

“It is disappointing that several months into the pandemic, we do not yet have results” from any strict tests of the drug, they wrote. Still, the new study “suggests that this treatment is not a panacea.”

President Donald Trump repeatedly urged the use of hydroxychloroquine, which is used now for lupus and rheumatoid arthritis. It has potentially serious side effects, including altering the heartbeat in a way that could lead to sudden death.

The U.S. Food and Drug Administration has warned against its use for coronavirus infections except in formal studies.

Doctors at Columbia tracked how 565 patients who did not get the drug fared compared to 811 others who received hydroxychloroquine with or without the antibiotic azithromycin, a combo Trump also has touted.

In all, 180 patients required breathing tubes and 232 died, and the drug did not seem to affect the odds of either.

Patients given hydroxychloroquine were generally sicker than the others, but widely accepted methods were used to take that into account and still no benefit was seen for the drug.

Its use started within two days of admission for nearly all who received it. Some critics of earlier studies have said treatment may have started too late to do any good.

The study was funded by the National Institutes of Health, which has launched two of its own trials comparing hydroxychloroquine to placebo — the gold standard for establishing safety and effectiveness.

One study involves COVID-19 patients, and the other aims to see whether the drug can help prevent infections in health care workers exposed to the virus. Both got started in April.
___
Marilynn Marchione can be followed on Twitter: @MMarchioneAP
___
The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content.

Today’s Top Stories

COVID-19: Vaccine Watch

A sign reading "immunizations" hangs over a desk. COVID-19 vaccines Utah...
Samantha Herrera

Where to find a COVID-19 vaccine provider for children 5 and under in Utah

COVID-19 vaccines are now available for children as young as 6 months old, but where can you find a vaccine provider for your child in Utah?
12 days ago
A child is comforted after getting his COVID-19 vaccine....
Samantha Herrera

More COVID-19 vaccines ordered in Utah for children as young as 6 months

32,000 doses of COVID-19 vaccines for children 6 months and older have been ordered by the Utah Department of Health and Human Services.
13 days ago
This combination of 2022 and 2020 file  photos shows logos for the U.S. Centers for Disease Control...
LAURAN NEERGAARD AP Medical Writer

Marathon US hearings to decide fate of COVID shots for tots

On Wednesday, both Moderna and Pfizer will argue their case. Each company aims to offer a different dose and number of shots.
25 days ago
FILE - A vial of the Phase 3 Novavax coronavirus vaccine is seen ready for use in the trial at St. ...
LOLITA C. BALDOR Associated Press

New vaccine may be option for troops with religious concerns

At least 175 active duty and reserve service members have received the Novavax vaccine. Some have traveled overseas at their own expense to get it.
26 days ago
utah student achievement COVID-19...
Simone Seikaly

Utah student performance knocked down during COVID-19 restrictions

A review of multiple Utah student performance exams found "significant impacts" in mathematics achievement across grades.
1 month ago
COVID-19 vaccine...
KEVIN McGILL

Opponents of federal vaccine mandate seek rehearing

Mr. Biden issued an order Sept. 9 that more than 3.5 million federal executive branch workers undergo vaccination, with no option to get regularly tested.
1 month ago

Sponsored Articles

Tax Harassment...
Jordan Wilcox

The best strategies for dealing with IRS tax harassment | You have options!

Learn how to deal with IRS tax harassment. This guide will teach you how to stop IRS phone calls and letters, and how to handle an IRS audit.
spend a day at Bear Lake...
Bear Lake Convention and Visitors Bureau

You’ll love spending the day at Bear Lake | How to spend a day at Bear Lake

Bear Lake is a place that needs to be experienced. Spend a day at Bear Lake.
Curb Appeal...
Price's Guaranteed Doors

How to have the best of both worlds for your house | Home security and curb appeal

Protect your home and improve its curb appeal with the latest security solutions like beautiful garage doors and increased security systems.
Prescription opioids can be disposed of during National Prescription Take Back Day...
Know Your Script

Prescription opioid misuse | How to protect your family from the opioid epidemic

Studies have shown that prescription opioid misuse has increased since COVID-19. So what do you need to know about these opioids?
national heart month...
Intermountain Healthcare

National Heart Month: 5 Lifestyle Changes to Make Today to Keep You Heart Healthy

Heart disease is the leading cause of death for both men and women. One person dies every 36 seconds in the United States from cardiovascular disease
Joseph Smith Memorial Building...
Temple Square

The Joseph Smith Memorial Building is an icon of Salt Lake City | Why hosting an event at this beautiful location will make you a hero this year

Here's why hosting an event at the iconic Joseph Smith Memorial Building in downtown Salt Lake City will make you a hero this year.
Malaria drug shows no benefit in another coronavirus study