HEALTH

Utah cancer researcher says new accelerated aging study needs more examination

Apr 20, 2024, 9:00 AM

The Huntsman Cancer Institute in Salt Lake City, Utah.A Utah cancer researcher says more study is n...

The Huntsman Cancer Institute in Salt Lake City, Utah.A Utah cancer researcher says more study is needed after new research links accelerated aging to certain types of cancers. (Jordan Allred/Deseret News)

(Jordan Allred/Deseret News)

SALT LAKE CITY — Accelerated aging may be linked to early-onset cancers. That’s according to new research presented at the annual meeting of the American Association for Cancer Research.

The researchers theorize that when someone’s biological age is greater than their chronological age, their risk for certain types of cancer increases.

However, a Utah cancer researcher said more peer review of the accelerated aging research is needed.

Taking a closer look at the accelerated aging study

Data from nearly 149,000 people in the U.K. was reviewed and presented in an abstract to the AACR.  The data was obtained using the UK Biobank database, which houses “de-identified medical and genetic data from half a million volunteer participants,” according to its website.

According to the abstract, the researchers “calculated each participant’s biological age using nine biomarkers found in blood.”  Biological aging occurs, according to the National Center for Biotechnology Information, “as a person gradually accumulates damages to various cells.”

They report that “people born in or after 1965 had a 17% higher likelihood of accelerated aging than those born between 1950 and 1954.”

“Multiple cancer types are becoming increasingly common among younger adults in the United States and globally,” said Ruiyi Tian, MPH, a graduate student in the lab of Yin Cao, ScD, MPH at Washington University School of Medicine in St. Louis and a study author.

“Understanding the factors driving this increase will be key to improving the prevention or early detection of cancers in younger and future generations.”

Are biological and chronological age supposed to be the same?

Cancer investigator Dr. Sheetal Hardikar of the Huntsman Cancer Institute said accelerated aging occurs when your biological age — “how well your body is working” — exceeds your chronological age, which is the age from birth.

And Hardikar said there are several things that could lead to accelerated aging.

“There’s genetics, there is lifestyle factors …(like) smoking behaviors, exercise, alcohol … diet … sleeping, stress,” Hardikar said.

Other factors to consider in accelerated aging include co-morbidities like diabetes, hypertension, or a heart condition.

“All of that affects your biological age,” Hardikar said. “And so your chronological age and biological age may actually not be the same.”

Limitations of the research

She said the abstract presented at the annual meeting in San Diego earlier this month needs to be studied on a broader scale. And, by additional researchers.

“This is not a full-blown published article that has undergone a rigorous peer review by multiple scientists,” Hardikar said.

“Usually, three reviewers will review a manuscript once you submit it to a journal. Then they will really look at the methods very carefully … and whether the interpretation made by the authors makes sense with respect to their methods and results.

U.K. biobank cohort

A “big limitation” said Hardikar, “is that (the research) is based off a well-known cohort called the U.K. Biobank cohort, so it’s only individuals from the United Kingdom.

“We need to be able to replicate similar results in much more diverse populations before we can really draw strong conclusions that accelerated aging may be related to cancers developing earlier,” she said.

How to measure biological age?

Another problem for Hardikar is that  researchers used only one “genetic clock or biological-aging clock to determine the age of study participants.”

“There are multiple other clocks that people have developed to estimate biological age of individuals.”

“There is no consensus in the literature as to which biological aging clock is better,” she said, adding a person’s “biological age may slightly differ based on what biological aging clock you have used.”

Don’t ‘jump the gun,’ says doctor

Hardikar concluded that Tian’s abstract reflects a “well-done study based off this limited information that we have in the abstract.”

“Scientists really need to be cautious when interpreting results that have not been reviewed as they would in a peer-review process before a manuscript gets published.

She said the conclusions “make sense,” to her. “But I don’t think I would jump the gun and say it’s aging that’s causing early onset cancers.”

“We really need to do a lot more investigation before we can draw that conclusion,” Hardikar said.

Related: Early-onset cancer rates rising for people ages 18 to 45

We want to hear from you.

Have a story idea or tip? Send it to the KSL NewsRadio team here.

Health

Adderall, used to treat ADHD shown - adhd diagnosis in children up...

Josuee Sanchez and Sam Herrera

Nearly 1 million more children had an ADHD diagnosis in 2022 than in 2016

A CDC study found that 11.4% of children between the ages of 3 and 17 had an ADHD diagnosis based on parent reports in 2022.

4 hours ago

food is sorted, kids more open to food insecurity during summer months...

Britt Johnson

Summertime leaves kids vulnerable to food insecurity

The president of the Utah Food Bank said kids who rely on school breakfast and lunch will face food insecurity this summer.

2 days ago

(Canva)...

Michelle Lee

The impact of spring colors on mental health

Let’s Get Moving Host Maria Shilaos spoke with Dr. Sally Augustin to learn how we can use spring colors to improve our mental health.

3 days ago

The Delta Center and the skyline in Salt Lake City on Wednesday, May 8, 2024. Jazz owner Ryan Smith...

Michael Camit

SLC’s Main Street redesign is open to suggestions from disabled Utahns

With proposals for the revitalization of downtown Salt Lake City, ADA experts want to hear from disabled Utahns.

5 days ago

Suicide Rock in Parley's Canyon in 2023, before the myrtle spurge was sprayed with treatment....

Lindsay Aerts, KSL TV

Roundup sprayed via drone in Millcreek, Parley’s canyons to kill invasive weed. DWR says it’s needed

In an attempt to kill weeds, the Department of Wildlife Resources sprayed pesticides in the foothills of Millcreek and Parley’s canyons.

5 days ago

Therapist talks about mental health for athletes in the olympics...

Allessandra Harris

Sports psychologist explains an Olympic athlete’s feelings of grief

It is common for Olympic athletes to experience feelings of grief when competing or after the events have ended.

6 days ago

Sponsored Articles

a doctor putting her hand on the chest of her patient...

Intermountain Health

Intermountain nurse-midwives launch new gynecology access clinic

An access clinic launched by Intermountain nurse-midwives provides women with comprehensive gynecology care.

Young couple hugging while a realtor in a suit hands them keys in a new home...

Utah Association of Realtors

Buying a home this spring? Avoid these 5 costly pitfalls

By avoiding these pitfalls when buying a home this spring, you can ensure your investment will be long-lasting and secure.

a person dressed up as a nordic viking in a dragon boat resembling the bear lake monster...

Bear Lake Convention and Visitors Bureau

The Legend of the Bear Lake Monster

The Bear Lake monster has captivated people in the region for centuries, with tales that range from the believable to the bizarre.

...

Live Nation Concerts

All the artists coming to Utah First Credit Union Amphitheatre (formerly USANA Amp) this summer

Summer concerts are more than just entertainment; they’re a celebration of life, love, and connection.

Mother and cute toddler child in a little fancy wooden cottage, reading a book, drinking tea and en...

Visit Bear Lake

How to find the best winter lodging in Bear Lake, Utah

Winter lodging in Bear Lake can be more limited than in the summer, but with some careful planning you can easily book your next winter trip.

Happy family in winter clothing at the ski resort, winter time, watching at mountains in front of t...

Visit Bear Lake

Ski more for less: Affordable ski resorts near Bear Lake, Utah

Plan your perfect ski getaway in Bear Lake this winter, with pristine slopes, affordable tickets, and breathtaking scenery.

Utah cancer researcher says new accelerated aging study needs more examination